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Journal Article 57

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targeted therapy 9

cancer 4

immunotherapy 4

Alzheimer’s disease 3

drug resistance 3

amyloid β-protein 2

cancer therapy 2

lung cancer 2

ALK fusion 1

FLT3 inhibitors 1

Salmonella VNP20009 1

AMLTargeted therapy 1

ARBs removal 1

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Adenovirus serotype 5 1

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Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11705-014-1454-6

Abstract: Previous studies have found that three peptide inhibitors (i.e., KLVFF, VVIA, and LPFFD) can inhibitHowever, atomic details of binding modes and binding affinities between these peptide inhibitors andmolecular mechanics Poisson Boltzmann surface area (MM/PBSA) analysis, we examined the effect of three peptideMM/PBSA analysis further revealed that different peptide inhibitors have different modes of interactionprovides structure-based binding information for further modification and optimization of these three peptide

Keywords： Alzheimer’s disease     amyloid β-protein     peptide inhibitors     protein-protein interaction     molecular    

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Cystine oligomers successfully attached to peptide cysteine-rich fibrils

Christian Bortolini,Mingdong Dong

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 99-102 doi: 10.1007/s11705-016-1554-6

Abstract: Amyloid peptides are renowned to be related to neurodegenerative diseases, however, a fruitful avenue is to employ them as high-performance nanomaterials. These materials benefit from the intrinsic outstanding mechanical robustness of the amyloid backbone made of -strands. In this work, we exploited amyloid-like fibrils as functional material to attach pristine L-cysteine aggregates (cystine oligomers) and gold nanoparticles, without the need of templating compounds. This work will open new avenues on functional materials design and their realisation.

Keywords： cysteine     peptide fibrils     gold nanoparticles     amyloids     oligomers     nanomaterials    

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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 368-373 doi: 10.1007/s11684-015-0403-1

Abstract:

Glucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental

Keywords： ischemia/reperfusion     liver     glucagon-like peptide-2     alanine aminotransferase    

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The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 437-442 doi: 10.1007/s11684-009-0074-x

Abstract: Natriuretic peptide precursor A (NPPA) is synthesized, stored, and released by atrial myocytes.

Keywords： natriuretic peptide precursor A     coronary heart disease     gene polymorphism     allelic discrimination     polymorphism    

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Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 245-255 doi: 10.1007/s11684-009-0044-3

Abstract: Therefore, this information may be applied for early cancer detection, classification, novel targetedRecent clinical data have revealed that targeted therapy might be the second-line therapy as an alternativeCurrently, the targeted therapies are mainly focused on two lung cancer pathways, the EGFR and the vascularTherefore, it is very important to select NSCLC patients with biomarkers to match targeted agents sothat we can further identify effectiveness of targeted therapy in the future.

Keywords： lung cancer     carcinoma     non-small cell lung cancer     molecular markers     targeted therapy    

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Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 9-19 doi: 10.1007/s11705-013-1306-9

Abstract: innovative silica-based, mucoadhesive oral insulin formulation with encapsulated-insulin/cell penetrating peptideIt was also confirmed that low molecular weight protamine (LMWP) behaves like a CPP peptide, with a celldevelopment of a generic platform for oral delivery of many other bioactive compounds, especially for peptide

Keywords： insulin     cell penetrating peptide     mucoadhesive composites     oral delivery    

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Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells

XIONG Ying, GUO Wen, LI Ting, LI Ke

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 304-307 doi: 10.1007/s11684-007-0058-7

Abstract: The transient transfection of survivin-targeted siRNA to Lovo cells and its influence on the biologicalTwo pairs of 19 base pairs (bp) siRNA-specific targeted survivin gene were designed and synthesized byAfter transient transfection of the two survivin-targeted siRNAs to Lovo cells by Lipofectamine™ 2000Based on the results, we can draw a conclusion that the two survivin-targeted siRNAs successfully suppressed

Keywords： control     therapy     influence     Survivin-1     colorectal carcinoma    

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A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Engineering doi: 10.1016/j.eng.2023.05.024

Abstract: This double-layer structure allows DPH to encapsulate and deliver probiotics in a targeted manner withinThus, DPH endows probiotics with excellent intestine-targeted delivery, improved oral bioavailability

Keywords： Polysaccharides     Chitosan     Hydrogels     Oral delivery     Intestine-targeted    

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Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation

Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,

Engineering doi: 10.1016/j.eng.2023.01.015

Abstract: In particular, a designed antifreeze peptide named AVD exhibits ideal ice recrystallization inhibitionanalysis and molecular dynamics (MD) simulations indicated that the Thr6 and Asn8 residues of the AVD peptideFurthermore, to demonstrate the cryoprotection potential of AVD, the peptide was successfully employedThis work opens up a new avenue for designing antifreeze materials and provides peptide-based functional

Keywords： Antifreeze peptides     Evolution analysis     Ice recrystallization inhibition     Molecular dynamics simulation     Cryopreservation     Synthetic biology    

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Progress and challenges in RET-targeted cancer therapy

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 207-219 doi: 10.1007/s11684-023-0985-y

Abstract: The rearranged during transfection (RET) is a receptor protein tyrosine kinase. Oncogenic RET fusions or mutations are found most often in non-small cell lung cancer (NSCLC) and in thyroid cancer, but also increasingly in various types of cancers at low rates. In the last few years, two potent and selective RET protein tyrosine kinase inhibitors (TKIs), pralsetinib (BLU-667) and selpercatinib (LOXO-292, LY3527723) were developed and received regulatory approval. Although pralsetinib and selpercatinib gave high overall response rates (ORRs), < 10% of patients achieved a complete response (CR). The RET TKI-tolerated residual tumors inevitably develop resistance by secondary target mutations, acquired alternative oncogenes, or MET amplification. RET G810 mutations located at the kinase solvent front site were identified as the major on-target mechanism of acquired resistance to both selpercatinib and pralsetinib. Several next-generation of RET TKIs capable of inhibiting the selpercatinib/pralsetinib-resistant RET mutants have progressed to clinical trials. However, it is likely that new TKI-adapted RET mutations will emerge to cause resistance to these next-generation of RET TKIs. Solving the problem requires a better understanding of the multiple mechanisms that support the RET TKI-tolerated persisters to identify a converging point of vulnerability to devise an effective co-treatment to eliminate the residual tumors.

Keywords： pralsetinib     selpercatinib     RET-alteration     lung cancer     thyroid cancer     tumor-agnostic therapy     drug resistance    

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Molecular classification and molecular targeted therapy of cancer

Miao Xu, Jianyong Shao, Yixin Zeng

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 147-149 doi: 10.1007/s11684-013-0274-2

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Multi-Peptide Adsorption on Uncharged Solid Surfaces: A Coarse-Grained Simulation Study Research

Ruosang Qiu, Jie Xiao, Xiao Dong Chen

Engineering 2020, Volume 6, Issue 2,   Pages 185-194 doi: 10.1016/j.eng.2018.12.012

Abstract: It was observed that around half (46.6%) of the 12-Ala peptide chains could form aggregates. 30.0% ofThe change in the solid-liquid interface due to peptide deposition has a potential influence on the furtheradsorption of single peptide chains and aggregates in the bulk water.Overall, the findings from this work help to reveal the mechanism of multi-peptide adsorption, and consequentially

Keywords： Peptide chains     Aggregates     Adsorption     Coarse-grained simulation    

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Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating

Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5,   Pages 889-901 doi: 10.1007/s11705-020-1919-8

Abstract: Herein, the multitargeting REDV-G-TAT-G-NLS peptide was conjugated to amphiphilic cationic copolymerECs-targeting ability, cell-penetrating ability and nuclear targeting capacity of REDV-G-TAT-G-NLS peptide

Keywords： gene carriers     multitargeting function     ECs     transfection efficiency    

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Microwave-induced high-energy sites and targeted energy transition promising for efficient energy deployment

Frontiers in Energy 2022, Volume 16, Issue 6,   Pages 931-942 doi: 10.1007/s11708-021-0771-y

Abstract: In this study, a high-energy-site phenomenon and targeted-energy transition mechanism were identifiedThe whole process, including microwave energy concentration and intense site-energy release, shapes a targeted-energyThe microwave-induced high-energy sites and targeted energy transition provide an important pathway for

Keywords： microwave discharge     high-energy sites     targeted-energy transition     morphology design     energy efficiency    

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Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging

Liangqian Tong, Ming Zhao, Shu Zhu, Jing Chen

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 379-387 doi: 10.1007/s11684-011-0162-6

Abstract: studies have shown the exciting potential of functionalized SPIO nanoparticles, such as surface-coated, targetedligand-conjugated, and/or drug-loaded SPIO nanoparticles, as powerful tools for targeted imaging andprimarily concentrate on the recent advancements in the field of SPIO nanoparticles in terms of synthesis, targeted

Keywords： nanoparticles     superparamagnetic iron oxide     targeted therapy     molecular imaging     cancer    

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Title Author Date Type Operation

Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Journal Article

Cystine oligomers successfully attached to peptide cysteine-rich fibrils

Christian Bortolini,Mingdong Dong

Journal Article

Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Journal Article

The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Journal Article

Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Journal Article

Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Journal Article

Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells

XIONG Ying, GUO Wen, LI Ting, LI Ke

Journal Article

A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Journal Article

Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation

Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,

Journal Article

Progress and challenges in RET-targeted cancer therapy

Journal Article

Molecular classification and molecular targeted therapy of cancer

Miao Xu, Jianyong Shao, Yixin Zeng

Journal Article

Multi-Peptide Adsorption on Uncharged Solid Surfaces: A Coarse-Grained Simulation Study

Ruosang Qiu, Jie Xiao, Xiao Dong Chen

Journal Article

Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating

Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng

Journal Article

Microwave-induced high-energy sites and targeted energy transition promising for efficient energy deployment

Journal Article

Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging

Liangqian Tong, Ming Zhao, Shu Zhu, Jing Chen

Journal Article